Actualités
Mieux détecter les pathologies avec le programme de recherche Cell-ID
Mieux détecter les pathologies avec le programme de recherche Cell-ID.
Financé par France 2030, le programme de recherche « Identités et destins cellulaires » (Cell-ID) explore la médecine d’interception, notamment pour mieux anticiper les cancers pédiatriques du cerveau.
25 novembre 2024
Les débuts du site web Cell-ID
La page d’accueil que vous visionnez actuellement a été publiée à l’occasion de l’inauguration du programme le 22 novembre. Le reste du site web est à venir !
20 novembre 2024
Phys. Rev. X 14, 041020 (2024) – DNA Replication and Polymer Chain Duplication Reshape the Genome in Space and Time
In eukaryotes, DNA replication constitutes a complex process whereby multiple origins are stochastically fired, and from which the replication machinery proceeds along chromosomes to achieve the faithful synthesis…
22 octobre 2024
Epigenomic heterogeneity as a source of tumour evolution | Nature Reviews Cancer
In the past decade, remarkable progress in cancer medicine has been achieved by the development of treatments that target DNA sequence variants…
16 octobre 2024
Global chromatin reorganization and regulation of genes with specific evolutionary ages during differentiation and cancer | BioRxiv
Cancer cells are highly plastic, allowing them to adapt to changing conditions. Genes related to basic cellular processes evolved in ancient species, while more specialized genes appeared later with multicellularity (metazoan genes) or even after mammals evolved…
14 octobre 2024
Axon guidance during mouse central nervous system regeneration is required for specific brain innervation | Developmental Cell
Reconstructing functional neuronal circuits is one major challenge of central nervous system repair. Through activation of pro-growth signaling pathways, some neurons achieve long-distance axon regrowth. Yet, functional reconnection has hardly been obtained…
30 septembre 2024
scConfluence: single-cell diagonal integration with regularized Inverse Optimal Transport on weakly connected features | Nature Communications
The abundance of unpaired multimodal single-cell data has motivated a growing body of research into the development of diagonal integration methods. However, the state-of-the-art suffers from the loss of biological information due to feature conversion and struggles with modality-specific populations…
5 septembre 2024
A point cloud segmentation framework for image-based spatial transcriptomics | Nature
Recent progress in image-based spatial RNA profiling enables to spatially resolve tens to hundreds of distinct RNA species with high spatial resolution. It presents new avenues for comprehending tissue organization. In this context, the ability to assign detected RNA transcripts to individual cells is crucial for downstream analyses, such as in-situ cell type calling…
6 juillet 2024
Multiplexed chromatin imaging reveals predominantly pairwise long-range coordination between Drosophila Polycomb genes | Cell Reports
Polycomb (Pc) group proteins are transcriptional regulators with key roles in development, cell identity, and differentiation. Pc-bound chromatin regions form repressive domains that interact in 3D to assemble repressive nuclear compartments. Here, we use multiplexed chromatin imaging to investigate whether Pc compartments involve the clustering of multiple Pc domains during Drosophila development….
25 mai 2024
Medulloblastomas with ELP1 pathogenic variants: A weakly penetrant syndrome with a restricted spectrum in a limited age window | Oxford Academic
ELP1 pathogenic variants (PV) have been recently identified as the most frequent variants predisposing to Sonic Hedgehog (SHH) medulloblastomas (MB); however, guidelines are still lacking for genetic counseling in this new syndrome…
15 mai 2024
EZH2 mutations in follicular lymphoma distort H3K27me3 profiles and alter transcriptional responses to PRC2 inhibition | Nature Communications
Mutations in chromatin regulators are widespread in cancer. Among them, the histone H3 lysine 27 methyltransferase Polycomb Repressive Complex 2 (PRC2) shows distinct alterations according to tumor type. This specificity is poorly understood. Here, we model several PRC2 alterations in one isogenic system to reveal their comparative effects…
24 avril 2024
Transient loss of Polycomb components induces an epigenetic cancer fate | Nature
Although cancer initiation and progression are generally associated with the accumulation of somatic mutations, substantial epigenomic alterations underlie many aspects of tumorigenesis and cancer susceptibility, suggesting that genetic mechanisms might not be the only drivers of malignant transformation.
24 avril 2024
Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses | Nature
Macroglia fulfill essential functions in the adult vertebrate brain, producing and maintaining neurons and regulating neuronal communication. However, we still know little about their emergence and diversification. We used the zebrafish D. rerio as a distant vertebrate model with moderate glial diversity as anchor to reanalyze datasets covering over 600 million years of evolution…
17 avril 2024
A cell fate decision map reveals abundant direct neurogenesis bypassing intermediate progenitors in the human developing neocortex | Nature Cell Biology
The human neocortex has undergone strong evolutionary expansion, largely due to an increased progenitor population, the basal radial glial cells. These cells are responsible for the production of a diversity of cell types, but the successive cell fate decisions taken by individual progenitors remain unknown. Here we developed a semi-automated live/fixed correlative imaging method to map basal radial glial cell division modes in early fetal tissue and cerebral organoids…
28 mars 2024
Diffuse midline glioma invasion and metastasis rely on cell-autonomous signaling | Oxfort Academic
Diffuse midline gliomas (DMG) are pediatric tumors with negligible 2-year survival after diagnosis characterized by their ability to infiltrate the central nervous system. In the hope of controlling the local growth and slowing the disease, all patients receive radiotherapy. However, distant progression occurs frequently in DMG patients…
3 mars 2024
Regulation of replicative histone RNA metabolism by the histone chaperone ASF1 | Molecular Cell
In S phase, duplicating and assembling the whole genome into chromatin requires upregulation of replicative histone gene expression. Here, we explored how histone chaperones control histone production in human cells to ensure a proper link with chromatin assembly. Depletion of the ASF1 chaperone specifically decreases the pool of replicative histones both at the protein and RNA levels…
15 février 2024
Homemade: building the structure of the neurogenic niche | Frontiers in Cell and Developmental Biology
Neural stem/progenitor cells live in an intricate cellular environment, the neurogenic niche, which supports their function and enables neurogenesis. The niche is made of a diversity of cell types, including neurons, glia and the vasculature, which are able to signal to and are structurally organised around neural stem/progenitor cells…
1 décembre 2023
Chromatin compartmentalization regulates the response to DNA damage | Nature
The DNA damage response is essential to safeguard genome integrity. Although the contribution of chromatin in DNA repair has been investigated1,2, the contribution of chromosome folding to these processes remains unclear3. Here we report that, after the production of double-stranded breaks (DSBs) in mammalian cells, ATM drives the formation of a new chromatin compartment (D compartment) through the clustering of damaged topologically associating domains, decorated with γH2AX and 53BP1…
18 octobre 2023
Self-organizing models of human trunk organogenesis recapitulate spinal cord and spine co-morphogenesis
Integrated in vitro models of human organogenesis are needed to elucidate the multi-systemic events underlying development and disease. Here we report the generation of human trunk-like structures that model the co-morphogenesis, patterning and differentiation of the human spine and spinal cord. We identified differentiation conditions for human pluripotent stem cells favoring the formation of an embryo-like extending antero-posterior (AP) axis…
14 septembre 2023
Live-cell micromanipulation of a genomic locus reveals interphase chromatin mechanics | Science
Publication de Veer I. P. Keizer, Simon Grosse-Holz, Maxime Woringer, Laura Zambon, Koceila Aizel, Maud Bongaerts, Fanny Delille, Lorena Kolar-Znika, Vittore F. Scolari, Sebastian Hoffmann, Edward J. Banigan, Leonid A. Mirny, Maxime Dahan, Daniele Fachinetti, Antoine Coulon, dans Science
28 juillet 2022
Regulation of developmental hierarchy in Drosophila neural stem cell tumors by COMPASS and Polycomb complexes | Science Advances
Publication de Cassandra Gaultier, Sophie Foppolo, Cédric Maurange, dans Science Advances
11 mai 2022
Temporal patterning in neural progenitors: from Drosophila development to childhood cancer | Disease Models & Mechanisms
Publication de Cédric Maurange, dans Disease Models & Mechanisms
22 juillet 2020
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