Publication
Phys. Rev. X 14, 041020 (2024) – DNA Replication and Polymer Chain Duplication Reshape the Genome in Space and Time
In eukaryotes, DNA replication constitutes a complex process whereby multiple origins are stochastically fired, and from which the replication machinery proceeds along chromosomes to achieve the faithful synthesis...
Epigenomic heterogeneity as a source of tumour evolution | Nature Reviews Cancer
In the past decade, remarkable progress in cancer medicine has been achieved by the development of treatments that target DNA sequence variants...
Global chromatin reorganization and regulation of genes with specific evolutionary ages during differentiation and cancer | BioRxiv
Cancer cells are highly plastic, allowing them to adapt to changing conditions. Genes related to basic cellular processes evolved in ancient species, while more specialized genes appeared later with multicellularity (metazoan genes) or even after mammals evolved...