Team

Research: Epigenetics, Chromatin biology, 3D genome organization, epigenetic inheritance and memory, Chromatin state transitions during differentiation and senescence

Methods: Chromosome Conformation Capture (3C, 4C, 5C, Hi-C, Capture-Hi-C, ChIA-PET, HiChIP), Chromatin Immunoprecipitation (ChIP, ChIP-seq), RNA sequencing (bulk & single-cell), DNA methylation profiling, Drosophila genetics, Protein–DNA mapping, Bioinformatics and Statistical modeling of gene regulation, Microscopy analysis

Technologies: Next-Generation Sequencing (NGS) platforms, Hi-C and related chromatin conformation technologies, ChIP-seq and CUT&RUN / CUT&Tag platforms, Confocal and live-cell microscopy, Super-resolution microscopy (STORM, SIM)

Research: Chromatin structure & 3D genome organization, Transcription regulation, Single-cell variability in gene expression and chromatin folding, DNA segregation complexes

Methods: Hi‑M: multiplexed DNA/RNA imaging (spatial genomics), Super-resolution microscopy (STORM, multifocus microscopy), Single-molecule localization microscopy (SMLM), Live imaging, Magnetic tweezers, Microfluidics

Technologies: Adaptive optics, Spatial genomics/transcriptomics pipelines, Long-range chromatin mapping, chromatin loops visualization, Multiplex imaging software, Data analysis platforms, chromatin folding modeling

Research: Pediatric neuro-oncology, Tumor microenvironment, Tumorigenesis in cerebellar development, Tumor cell plasticity and resistance, Cancer cell heterogeneity, Pediatric cancer immunotherapy, Translational research in childhood oncology

Methods: Proteomics and mass spectrometry, Nanopore sequencing, Multi-omics approaches, ScRNA sequencing, In vivo mouse models, Tumor microenvironment analysis, High-throughput screening for therapeutic targets

Technologies: Advanced sequencing platforms, Mass spectrometry-based proteomics, Single-cell sequencing technologies, Multiplex immunofluorescence imaging, Data integration platforms for multi-omics data, Computational modeling of tumorigenesis